Many individuals with disabling conditions have difficulty with gait and balance control that may result in a fall. Exoskeletons are becoming an increasingly popular technology to aid in walking. Despite being a significant aid in increasing mobility, little attention has been paid to exoskeleton features to mitigate falls. To develop improved exoskeleton stability, quantitative information regarding how a user reacts to postural challenges while wearing the exoskeleton is needed. Assessing the unique responses of individuals to postural perturbations while wearing an (...) exoskeleton provides critical information necessary to effectively accommodate a variety of individual response patterns. This report provides kinematic and neuromuscular data obtained from seven healthy, college-aged individuals during posterior support surface translations with and without wearing a lower limb exoskeleton. A 2-min, static baseline standing trial was also obtained. Outcome measures included a variety of 0 dimensional measures such as center of pressure RMS, peak amplitude, velocities, pathlength, and electromyographic RMS, and peak amplitudes. These measures were obtained during epochs associated with the response to the perturbations: baseline, response, and recovery. T-tests were used to explore potential statistical differences between the exoskeleton and no exoskeleton conditions. Time series waveforms of the COP and EMG data were also analyzed. Statistical parametric mapping was used to evaluate the 1D COP and EMG waveforms obtained during the epochs with and without wearing the exoskeleton. The results indicated that during quiet stance, COP velocity was increased while wearing the exoskeleton, but the magnitude of sway was unchanged. The OD COP measures revealed that wearing the exoskeleton significantly reduced the sway magnitude and velocity in response to the perturbations. There were no systematic effects of wearing the exoskeleton on EMG. SPM analysis revealed that there was a range of individual responses; both behaviorally and among neuromuscular activation patterns. Using both the OD and 1D measures provided a more comprehensive representation of how wearing the exoskeleton impacts the responses to posterior perturbations. This study supports a growing body of evidence that exoskeletons must be personalized to meet the specific capabilities and needs of each individual end-user. (shrink)

SummaryThe Istituto e Museo di Storia della Scienza, Florence, Italy, possesses an astrolabe with five latitude plates that is now attributed to the Duisburg workshop of Gerard Mercator. Although it is known that Mercator made instruments, this is the first surviving example to be identified. Another latitude plate is shown to come from the workshop of the Florentine, Giovan Battista Giusti. A seventh plate, possibly engraved by Rumold Mercator, provides the only known Mercatorian polar stereographic projection. The role of Egnazio (...) Danti, cosmographer to the Grand Duke of Tuscany, in the acquisition of the astrolabe in about 1570 is considered. (shrink)

In a paper published in volume 50 of Annals of Science an astrolabe at the Istituto e Museo di Storia della Scienza, Florence, was attributed to the hand of Gerard Mercator, c. 1570, when his workshop was in Duisburg. This was the first scientific instrument by Mercator to be identified. Since then two further astrolabes by Mercator have been identified, one of them bearing his monogram: GMR. They belong to the Städtische Kunstsammlungen, Augsburg, and the Moravian Gallery, Brno. All three (...) instruments are described as a group, and reasons for believing that the Brno astrolabe was made earlier than 1550, and therefore in Louvain, are given. (shrink)

Porté aux nues par les écrivains du XIXè siècle qui voyaient en lui le type même du poète maudit, Byron (1788-1824) a subi au XXè siècle un long purgatoire avant d'être enfin reconnu comme une personnalité littéraire de premier plan. Après les traductions en prose du siècle dernier qui, malgré leur mérite, n'offraient qu'un pâle reflet, on redécouvre aujourd'hui toute la virtuosité d'un poète qui jongle avec les rimes et les rythmes et qui demandait donc à être traduit en vers. (...) Ce choix de poèmes n'a d'autre ambition que de donner une meilleure idée de ses œuvres les plus célèbres. On y retrouva des poèmes de circonstances qui transcendent l'anecdote autobiographique, des morceaux de bravoure qui ont fait la réputation de Childe Harold et de Don Juan, sans oublier cet hymne vibrant à la liberté qu'est le Prisonnier de Chillon et, pour finir, la dernière tirade de Marino Faliero, drame peu connu en France et suprême hommage du poète anglais à la Venise de son imagination. (shrink)

To answer the question in the title, we take as an example the model for the regulation of agonistic antagonistic couples (MRAAC). It is a model that associates 4 non-linear differential equations and allows to simulate balance, imbalance between two state variables, and control, if necessary, by two control variables of the same nature as the state variables: this control is defined as a bilateral strategy (bipolar therapy in the medical field). The super model for the regulation of agonism antagonistic (...) couples (SMRAAC), that may be also considered as an agonistic antagonistic network (AAN), associates several elementary MRAAC's, but the interconnection structure falls equally under the category of the agonistic antagonism (AA). First we indicate what may be the results of the interconnection, favourable or not. In the last case, a control can be performed, by acting upon a sole couple of the SMRAAC, even if other couples were imbalanced (with two AA control variables only). Simulation examples are given. We bring also a new result with the SMRAAC, i.e. the appearance of strange auractors with this model. The general models belonging to the AA phylum should put on a growing importance in the future, because they could be the sole models enable to control some complex systems by avoiding the perverse effects of the unilateral strategies. (shrink)

New class of therapies, including bipolar therapies (BPT) and paradoxical unipolar therapies (PUT) were firstly proposed in relation to a clinical insight and to some results of biological investigations, then they gave rise to mathematical modeling which brought a justification of these therapies, at least from a theoretical point of view. After recalling the mathematical model for the regulation of agonistic antagonistic couples, and reporting the fundamental types of control simulation by means of it, we point out the validity of (...) therapeutical applications inferred from this model. These therapy modalities, including BPT and PUT, now concern the following diseases: astrocytomas, epilepsia and trials on multiple sclerosis. Even if such attempts are in their early stage, noticeably for the last case where biological changes have mainly been studied, it seems that a large span of treatments is open to BPT and PUT. Improvement of these techniques in the future depends, in our opinion, on a parallel working on the dynamics of the mathematical model and the dynamics, perceived by clinical insight and confirmed by biological investigations, of the body reactions to such strategies. Justification of BPT and PUT was given, by resorting to the notion of pathological homeostasis which, too often, intervenes in order to nullify the effects of unilateral (not paradoxical) therapies. This research has elicited some therapies which use two agents with antagonistic effects or only an agent with effects similar to the agent already in excess in the body - in both cases at nearly physiological doses. (shrink)

A link between biological and human sciences may be established, under the condition that we should admit the existence of reciprocal influences between them. The model for the regulation of agonistic antagonistic couples (MRAAC) is built from the study of biological systems and gives rise to specific types of control. This model can be helpful in decision processes in some human sciences such as management, economical and political strategies. The reason for such an opportunity lies in the fact that MRAAC (...) is a general and phenomenological model able to incorporate the whole of the agonistic antagonistic systems. This type of regulation might be related to the concept of the viability of a system (yet also valid for human science systems) and to a functional and structural pattern which is the basis for agonistic antagonistic networks. (shrink)

There are many reasons for questioning the relevance of the concepts of self-organization (SO) and emergence. By studying three types of SO, respectively related to ontogeny, phylogeny and formalized models, we show that we always have to suppose an associated hetero-organization and preconceived immergence, unconsciously present in the authors mind. In order to understand how these unusual couples are working, they must be considered as agonistic antagonistic couples. Heteroorganization and immergence put constraints on the system so that SO and emergence (...) will produce new patterns and forms, depending on these constraints. Besides, such couples (SO and heteroorganization, emergence and immergence) seem to belong to a series of couples of the same type, allowing us to define a kind of model of life.The concept of self-organization has been presented as the main concept defining systemics, and second order cybernetics. This concept has been accepted also in general Biological Theory (BT) where authors endowed the key to many phenomena until then poorly understood. (shrink)

The concept of a technical frontier in branches of experimental measurement, such as the resolution of the microscope, angular measure and time telling, has been around for more than 60 years. The purpose of this brief paper is to identify the technical frontier operating on the achromatic astronomical telescope, where a limiting factor of the resolution of fine detail was the quality of the optical glass available. The achromatically corrected objective is formed from two kinds of glass, the common crown (...) glass and the heavy clear flint glass or lead glass. This last was difficult to make homogeneous, that is without regions of different density, and therefore different refraction and dispersion. Unusually, optical glass had to pass a second frontier, this time placed on the whole glass industry by the English Government in the form of excise duty, administered with a bureaucratic efficiency that effectively stopped, in around 1800, the making of optical glass suitable for the serious astronomical telescopes. The result of the tax imposition was to delay the English production of improved optical glass for more than 80 years. (shrink)

The general view is that there is one type of nocturnal, which is universal, first illustrated in a printed book in 1524. Recently, a number of quite differently constructed nocturnals has come to light. Six of these were made at the very beginning of the sixteenth century by Falcono of Bergamo in northern Italy. One of them, with the initials of the inventor, may well be the prototype. Five more are closely similar. Five further nocturnals of the same type have (...) been identified, but they are unsigned, and are not by Falcono. This paper establishes the existence of a hitherto unrecognized Italian workshop, and of a variant type of nocturnal. (shrink)

Résumé — L’analyse de la condition ouvrière dévoile les conditions sociales de la constitution psychologique et morale de soi. Le système tayloriste est aliénant en ce qu’il anéantit la capacité de s’attribuer réalité et valeur, en forçant l’ouvrier à endosser des mobiles qu’il ne peut pourtant s’approprier car ils lui sont étrangers et humiliants, contraires à ses aspirations. Il dépend de l’extériorité – où il peut certes trouver des grandeurs de conventions mensongères, mais aussi ce qui lui est le plus (...) intérieur – pour comprendre les aspirations qui le constituent et rester en accord avec lui-même. Il ne faut donc pas opposer l’intériorité indépendante et l’extériorité, mais deux types de dépendance : à la force extérieure, qui brise le rapport à soi ; ou à la nécessité, intelligible, qui en permet l’instauration : il y a des conditions à l’autonomie morale, entendue comme capacité d’agir d’après l’intellection de la nécessité, seul mobile que le sujet peut s’approprier et qui l’élève. Cela permet de juger les sociétés, acceptables si leur fonctionnement est intelligible, si elles stimulent l’activité de compréhension, et offrent un milieu où sont exprimées les aspirations, la réalité et la valeur propres à l’individu.— The analysis of the working condition reveals the social conditions of the self psychological and moral constitution. The taylorist system is alienating since it annihilates the capacity to claim any reality and value, by forcing the workman to shoulder mobiles that he cannot afford because they are foreign and humiliating to him, opposites with his aspirations. Depending on the exteriority – where he can certainly find greatnesses of untrue conventions, but also what is most inner to him – he can understand the aspirations which constitute him and though remain in agreement with himself. One thus should not oppose independent interiority and the exteriority, but two types of dependence : on the external force, which breaks the relation with the self ; or on the necessity, intelligible, that allows the setting-up of it : there are conditions to moral autonomy, understood as the capacity to act according to the intellection of the necessity, sole mobile that the subject can take over and that emancipates him. That allows to evaluate the societies, acceptable if their way of processing is intelligible, if they stimulate the understanding activity, and offer a medium where the aspirations, reality and value that are peculiar to the individual are expressed. (shrink)

Simone Weil's Leçons de Philosophie are derived from a course she taught at the lyce;e for girls at Roanne in 1933-4. Anne Reynaud-Gue;rithault was a pupil in the class; her notes are not a verbatim record but are a very full and, as far as one can judge, faithful rendering, often catching the unmistakable tone of Simone Weil's voice as well as the force and the directness of her thought. The lectures form a good general introduction to philosophy, (...) ranging widely over problems about perception, mind, language, reasoning and problems in moral and political philosophy too. Her method of presentation is a characteristic combination of abstract argument, personal experience and literary or historical reference. Peter Winch points out in his introduction to the book some of the more systematic connections in her philosophical work (and between this philosophical work and her other concerns), and makes a number of suggestive comparisons between Simone Weil and Wittgenstein. The translation is by Hugh Price from the Plon edition of 1959. Dr Price has added some notes to explain references in the text that might be unfamiliar to English speaking students beginning philosophy. (shrink)

The active debate about the return of incidental or secondary findings in research has primarily focused on return to research participants, or in some cases, family members. Particular attention has been paid to return of genomic findings. Yet, research may generate other types of findings that warrant consideration for return, including findings related to the pathology of donated biospecimens. In the case of deceased biospecimen donors who are also organ and/or tissue transplant donors, pathology incidental findings may be relevant not (...) to family members, but to potential organ or tissue transplant recipients. This paper will describe the ethical implications of pathology incidental findings in the Genotype-Tissue Expression project, the process for developing a consensus approach as to if/when such findings should be returned, possible implications for other research projects collecting postmortem tissues and how the scenario encountered in GTEx fits into the larger return of results/incidental findings debate. (shrink)

Citing of previous publications is an important factor in knowledge development. Because of the great amount of publications available, only a selection of studies gets cited, for varying reasons. If the selection of citations is associated with study outcome this is called citation bias. We will study determinants of citation in a broader sense, including e.g. study design, journal impact factor or the funding source of the publication. As a case study we assess which factors drive citation in the human (...) literature on phthalates, specifically the metabolite mono phthalate. A systematic literature search identified all relevant publications on human health effect of MEHP. Data on potential determinants of citation were extracted in duplo. Specialized software was used to create a citation network, including all potential citation pathways. Random effect logistic regression was used to assess whether these determinants influence the likelihood of citation. 112 Publications on MEHP were identified, with 5684 potential citation pathways of which 551 were actual citations. Reporting of a harmful point estimate, journal impact factor, authority of the author, a male corresponding author, research performed in North America and self-citation were positively associated with the likelihood of being cited. In the literature on MEHP, citation is mostly driven by a number of factors that are not related to study outcome. Although the identified determinants do not necessarily give strong indications of bias, it shows selective use of published literature for a variety of reasons. (shrink)

Devant un film de Jean Cocteau ou de Pasolini, devant un scénario de Jacques Prévert ; devant les photos de Georges Azenstarck, celles des prêtres-ouvriers par Joël Peyroux, celles des albums de familles en banlieue ; devant les toiles de Patrice Giorda ou d'Ernest Pignon-Ernest mais aussi devant une page des Cantos d'Ezra Pound ou d'un texte d'Antonin Artaud, qui ne s'est posé la question : qu'est-ce qu'on y voit? Et plus interrogateur encore : qu'est-ce qu'on y lit? Les sources (...) d'inspiration, d'enthousiasmes ou de fureur de Gérard Mordillat sont nombreuses. Et c'est bien l'oeil qui toujours a nourri sa littérature. Ce recueil prend les ouvres à bras-le-corps, les dissèque, les malmène, pour en livrer toute la profondeur. Homme de lettres et homme d'images, Gérard Mordillat nous livre ici son regard de critique, au sens le plus noble du terme, avec la force et la fougue que l'on trouve dans ses romans. Au regard de textes écrits séparément mais tous gouvernés par cette même question : le mot et l'image seraient-ils frères de sang de l'écriture? Gérard Mordillat interroge les ouvres picturales, photographiques, littéraires ou cinématographiques qui, depuis toujours, sous-tendent et ses films et ses livres. (shrink)

What were Shakespeare's final thoughts on history, tragedy, and comedy? Shakespeare's Last Plays focuses much needed scholarly attention on Shakespeare's "Late Romances." The work--a collection of newly commissioned essays by leading scholars of classical political philosophy and literature--offers careful textual analysis of Pericles, Prince of Tyre, Cymbeline, The Winter's Tale, The Tempest, All is True, and The Two Noble Kinsmen. The essays reveal how Shakespeare's thought in these final works compliments, challenges, fulfills, or transforms previously held conceptions of the playwright (...) and his political-philosophical views. (shrink)

A leitura que Hegel faz da antinomia em Kant permite entender que as considerações deste não estão isentas de pressupostos antropológicos e de que, portanto, ele estuda a finitude das categorias nelas mesmas, mas em sua pertinência ao "sujeito", que, no final das contas, é um sujeito "psicológico". Eis o interesse que há em retormar os textos de Hegel para fazer jus à "arte de ler" hegeliana.

Pour sortir des intégrismes et en finir avec la violence.

La pensée du jurisconsulte anglais Jeremy Bentham (1748-1832) se prête particulièrement bien à une approche interdisciplinaire telle que celle qui est menée dans le présent ouvrage. Si Bentham, en effet, a consacré l'essentiel de ses travaux à des projets de réforme de la société anglaise de son temps par le biais de la codification des lois, il n'a cessé d'enrichir cette réflexion par des emprunts faits à d'autres disciplines, dans lesquelles il était également passé maître, telles la morale, la psychologie, (...) la logique, la théorie du langage, l'économie ou la politique.Cette pensée, à la fois plurielle et ambiguë (est-elle conservatrice, réformiste, révolutionnaire ou utopique? Est-elle descriptive, explicative ou normative?), révèle aujourd'hui son étonnante actualité. Il est peu de thèmes juridiques contemporains qui ne trouvent en effet leur place dans l'oeuvre de Bentham : ainsi les questions de l'utilité, de la balance des intérêts, de la constitution d'une science du droit et d'une logique déontique ; ainsi les concepts de système juridique, de codification, de déontologie, de contrôle social, d'opinion publique et de majorité politique. L'intérêt de cette « relecture » de la pensée de Bentham réside dès lors sans doute moins dans l'exégèse de ses multiples détours que dans la mise en lumière de ses ambiguïtés et de ses limites qui, pour une large part, sont aussi les nôtres. Parmi celles-ci, l'oscillation constante, déjà inscrite dans les textes benthamiens, entre deux figures de l'État moderne (État libéral et État-providence), n'est sans doute pas la moins actuelle. (shrink)